Understanding genetic changes in brain cells affected by Alzheimer's disease
Official title: Illuminating neurodegenerative tauopathy from somatic genomic landscapes of single human brain cells
Funded at Brigham and Women's Hospital · NIH-10686570 · Data updated 2026-11-12
This study is looking at the tiny genetic changes in brain cells from people with Alzheimer's and other brain diseases to help us understand how these changes affect the cells and contribute to the progression of the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 15, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $1,611,000 |
| NIH project number | 1DP2AG086138-01 |
| Project ID | NIH-10686570 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or primary tauopathies.
✕Less likely to help
Patients with neurodegenerative diseases not related to tauopathies or Alzheimer's may not benefit from this research.
What this research studies
This research investigates the genetic mutations in individual brain cells of patients with Alzheimer's disease and other neurodegenerative conditions. By utilizing advanced single-cell whole-genome sequencing techniques, the study aims to uncover the specific genetic alterations that contribute to cellular dysfunction in these diseases. The research will analyze brain tissue from affected individuals and use cellular models to explore the mechanisms behind these mutations. This approach could lead to a better understanding of how Alzheimer's disease progresses at the cellular level.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the causes of Alzheimer's disease and potentially identify targets for therapeutic intervention.
How similar studies have gone: Previous research has shown promising results in understanding genetic mutations in neurodegenerative diseases, making this approach both relevant and potentially impactful.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Miller, Michael B — Brigham and Women's Hospital
- Study coordinator: Miller, Michael B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.