Understanding genetic changes in Alzheimer's disease at the single neuron level
Official title: Mechanisms of Somatic Mutation in Alzheimer's Disease Using Single Neuron Analysis
Funded at Brigham and Women's Hospital · NIH-11003738 · Data updated 2026-11-12
This study is looking at the changes in brain cells caused by Alzheimer's disease to better understand how the disease progresses and to find new ways to help treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $804,192 |
| NIH project number | 5R01AG082346-02 |
| Project ID | NIH-11003738 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease, particularly those at different stages of the condition.
✕Less likely to help
Patients with other forms of dementia or neurological disorders unrelated to Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the genetic mutations that occur in neurons affected by Alzheimer's disease (AD) using advanced techniques that analyze individual brain cells. By examining postmortem brain tissue, the study aims to uncover how these mutations relate to the progression of AD and the misfolding of proteins like amyloid beta and tau. The researchers will look at neurons from individuals at various stages of AD to determine when these mutations arise and how they are influenced by disease-related factors. This approach could provide new insights into the cellular mechanisms underlying AD and potentially identify targets for future therapies.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of Alzheimer's disease mechanisms, paving the way for new treatment strategies.
How similar studies have gone: Previous research has shown promising results in understanding genetic mutations in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Miller, Michael B — Brigham and Women's Hospital
- Study coordinator: Miller, Michael B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.