Understanding genetic changes in African American patients with Multiple Myeloma
Defining the landscape of structural alterations in African American Multiple Myeloma
This study is looking at the genetic changes in African American patients with Multiple Myeloma to understand why they often have worse outcomes, even when their genes suggest they should do better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10651845 on NIH RePORTER |
What this research studies
This research investigates the genetic alterations associated with Multiple Myeloma, particularly focusing on African American patients who are disproportionately affected by this disease. The study aims to identify specific genomic changes that may contribute to the development and progression of Multiple Myeloma in this population. By analyzing the genetic makeup of patients, researchers hope to uncover why African Americans experience worse outcomes despite having genomic alterations that suggest a better prognosis. The methodology includes genomic sequencing and analysis of patient samples to correlate genetic findings with clinical outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are African American individuals diagnosed with Multiple Myeloma or its precursor condition, Monoclonal Gammopathy of Undetermined Significance (MGUS).
Not a fit: Patients who do not have Multiple Myeloma or MGUS, or those outside the African American demographic, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment strategies for African American patients with Multiple Myeloma.
How similar studies have performed: While there has been research on Multiple Myeloma, this specific focus on African American patients and their unique genetic landscape is relatively novel.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Boise, Lawrence H. — Emory University
- Study coordinator: Boise, Lawrence H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.