Understanding genetic changes in a type of leukemia that affects Hispanic populations.
Defining the Mechanism of Genome Rearrangements in Ph-Like ALL to Determine Predictive Markers in High-Risk Hispanic Populations
This study is looking into a type of leukemia called Ph-like ALL that affects many Hispanic teens and young adults, and it aims to understand the genetic changes behind it to help doctors make better treatment choices for patients like you.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11014401 on NIH RePORTER |
What this research studies
This research investigates Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL), a subtype of leukemia that significantly impacts Hispanic adolescents and young adults. The study aims to uncover the genetic mechanisms behind this condition, particularly focusing on the CRLF2 gene rearrangements that are prevalent in this population. By analyzing how these genetic changes occur and their relationship to patient outcomes, the research seeks to develop predictive markers that can guide treatment decisions. Patients may be involved in providing genetic samples to help identify these markers and improve future therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are Hispanic adolescents and young adults diagnosed with Philadelphia chromosome-like acute lymphoblastic leukemia.
Not a fit: Patients who do not have Ph-like ALL or are not of Hispanic descent may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and targeted therapies for Hispanic patients suffering from Ph-like ALL.
How similar studies have performed: Previous research has indicated disparities in leukemia outcomes among different populations, suggesting that targeted studies like this one could yield significant insights.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Pannunzio, Nicholas — University of California-Irvine
- Study coordinator: Pannunzio, Nicholas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.