Understanding genetic causes of monogenic diabetes for better diagnosis
Official title: Deep Mutational Scanning of Monogenic Diabetes Genes to Facilitate Precision Diagnostics for Diabetes
Funded at Stanford University · NIH-11177760 · Data updated 2026-11-12
This study is looking at the genetic changes that cause monogenic diabetes, which is a rare type of diabetes, to help doctors better understand and treat patients with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $657,261 |
| NIH project number | 5R01DK140555-02 |
| Project ID | NIH-11177760 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with monogenic diabetes or those with a family history suggesting a genetic cause of their diabetes.
✕Less likely to help
Patients with type 2 diabetes or other forms of diabetes not linked to single-gene mutations may not benefit from this research.
What this research studies
This research investigates the genetic mutations responsible for monogenic diabetes, which affects a small percentage of diabetes patients. By using advanced techniques to analyze how these mutations impact protein function, the study aims to create a detailed map of genetic variations. This information will help healthcare providers make more accurate diagnoses and tailor treatments for patients with monogenic diabetes. The approach involves sophisticated assays and collaboration with expert panels to ensure reliable results.
Why it matters
Potential benefit: If successful, this research could lead to more precise diagnostics and personalized treatment options for patients with monogenic diabetes.
How similar studies have gone: Previous research has shown promise in using genetic mapping techniques for precision medicine, indicating a strong potential for success in this area.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Gloyn, Anna Louise — Stanford University
- Study coordinator: Gloyn, Anna Louise
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.