Understanding Genetic Causes of Birth Defects
Integrated Genomics Core
This core facility helps researchers find the genetic changes that lead to birth defects by analyzing DNA from children and their parents.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11121910 on NIH RePORTER |
What this research studies
This core facility provides advanced genomic services to several research projects focused on birth defects. It helps researchers sequence the DNA of children and their parents to pinpoint genetic differences that might cause these conditions. The core also supports studies using advanced lab techniques on animal models and human cells to understand how development goes wrong. By bringing together all this genetic information, the core aims to accelerate discoveries about the origins of birth defects.
Who could benefit from this research
Good fit: Patients who are part of patient-parent trios, particularly children aged 0-11 years with birth defects, are ideal candidates for the research projects supported by this core.
Not a fit: Patients not directly involved in the specific research projects supported by this core, or those with conditions unrelated to birth defects, may not directly benefit from this particular grant.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of the genetic causes of birth defects, potentially guiding future diagnoses and treatments.
How similar studies have performed: Genomic sequencing and bioinformatics are well-established methods, and this core builds upon these successful approaches to integrate data from multiple projects.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Shen, Yufeng — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Shen, Yufeng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.