Understanding genetic and metabolic factors in prostate cancer for diverse men
Integrating Genomics and Metabolomics to Develop Predictive Models of Prostate Cancer in Multiethnic Men
['FUNDING_OTHER'] · FRED HUTCHINSON CANCER CENTER · NIH-10880395
This study is looking at how genes and other factors affect the risk of prostate cancer, especially in men of African descent, to create a tool that helps predict who might be at higher risk, and it invites patients to share their health information and samples to help improve prevention and treatment.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | FRED HUTCHINSON CANCER CENTER (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10880395 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic and metabolic factors that contribute to prostate cancer risk, particularly in men of African ancestry who are disproportionately affected by this disease. The study aims to develop a multiethnic polygenic risk score (PRS) that incorporates data from a diverse population to improve predictive accuracy for prostate cancer. By utilizing a large sample size and advanced statistical methods, the research seeks to identify key genetic variants and environmental influences that may lead to better prevention and treatment strategies for prostate cancer. Patients may be involved in providing biological samples and health data to support this important work.
Who could benefit from this research
Good fit: Ideal candidates for this research include men of African ancestry, as well as those from other ethnic backgrounds who are at risk for prostate cancer.
Not a fit: Patients who do not have a family history of prostate cancer or those who are not of African ancestry may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate risk assessments and personalized prevention strategies for prostate cancer in multiethnic populations.
How similar studies have performed: Previous research has shown promise in using genetic and metabolic data to improve cancer risk prediction, but this specific approach focusing on multiethnic populations is relatively novel.
Where this research is happening
SEATTLE, UNITED STATES
- FRED HUTCHINSON CANCER CENTER — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DARST, BURCU FRANCES — FRED HUTCHINSON CANCER CENTER
- Study coordinator: DARST, BURCU FRANCES
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Cause