Understanding genetic and metabolic factors in Alzheimer's disease among diverse populations
Official title: Epidemiological Integration of Genetic Variants and Metabolomics Profiles in Washington Heights Columbia Aging Project
Funded at Columbia University Health Sciences · NIH-10875725 · Data updated 2026-11-12
This study is looking at how our genes and body chemistry might affect the risk of developing Alzheimer's disease, especially in different communities in Washington Heights, and it involves regular check-ups and tests for participants to help us learn more about this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 30, 2020 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $1,525,349 |
| NIH project number | 4R01AG066107-02 |
| Project ID | NIH-10875725 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include African American individuals and other ethnic groups who are at risk for Alzheimer's disease or are interested in understanding their genetic and metabolic health.
✕Less likely to help
Patients who do not belong to the targeted ethnic groups or who do not have a family history of Alzheimer's disease may not receive direct benefits from this research.
What this research studies
This research investigates how genetic variants and metabolomic profiles contribute to the risk and prevention of Alzheimer's disease, particularly focusing on diverse populations in Washington Heights. By analyzing biological samples and clinical data from a multi-ethnic cohort, the study aims to identify environmental and genetic risk factors associated with Alzheimer's. Participants undergo medical examinations and cognitive assessments every 18 months, allowing researchers to track changes over time and understand the interplay between genetics, metabolism, and disease progression.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing Alzheimer's disease and personalized treatment options based on genetic and metabolic profiles.
How similar studies have gone: Previous studies have shown promise in understanding the relationship between genetics and Alzheimer's disease, but this research aims to expand on those findings by including a more diverse population.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Mayeux, Richard P — Columbia University Health Sciences
- Study coordinator: Mayeux, Richard P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.