Understanding genetic and lifestyle factors in endometrial cancer risk across different ancestries
Official title: Development of integrated risk models of genetic and non-genetic risk factors in endometrial cancer across diverse ancestries
Funded at Feinstein Institute for Medical Research · NIH-10990387 · Data updated 2026-11-12
This study is looking at why more Black women are getting endometrial cancer and aims to create better ways to understand their risk by combining genetic information with lifestyle factors, so that we can help with early detection and personalized care for those at risk.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Feinstein Institute for Medical Research NIH-funded |
| Lab location | 1 site (Manhasset, United States) |
| Project start | September 2, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $456,103 |
| NIH project number | 1R21CA294233-01 |
| Project ID | NIH-10990387 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals from racially and ethnically diverse backgrounds who may be at risk for endometrial cancer.
✕Less likely to help
Patients with no genetic predisposition or lifestyle risk factors associated with endometrial cancer may not benefit from this research.
What this research studies
This research investigates the rising incidence of endometrial cancer (EC), particularly among Black women, by exploring the interplay of genetic and non-genetic risk factors. It aims to develop advanced risk models that integrate genetic data with lifestyle factors such as BMI and diabetes history, using diverse biobank datasets. By focusing on underrepresented populations, the project seeks to enhance early detection techniques and provide personalized risk assessments for EC. The goal is to improve understanding and outcomes for patients at risk of this disease.
Why it matters
Potential benefit: If successful, this research could lead to improved early detection and personalized risk assessments for endometrial cancer, ultimately reducing mortality rates.
How similar studies have gone: Previous research has shown success in using integrated risk models for cancer detection, suggesting a promising approach for this study.
Where this research is happening
-
Feinstein Institute for Medical Research
Manhasset, United States Active
Researchers
- Principal investigator: Chambwe, Nyasha — Feinstein Institute for Medical Research
- Study coordinator: Chambwe, Nyasha
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.