Understanding genetic and immune factors that protect against Plasmodium vivax malaria
Official title: Comprehensive characterization of the genetic factors and the host immune response associated to protection from clinical Plasmodium vivax malaria
Funded at Institut Pasteur Du Cambodge · NIH-11021016 · Data updated 2026-11-12
This study is looking at why some people in Cambodia are able to resist Plasmodium vivax malaria, and it aims to find out how their genes and immune systems help them stay healthy, which could lead to better ways to prevent malaria for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Institut Pasteur Du Cambodge NIH-funded |
| Lab location | 1 site (Phnom Penh, CAMBODIA) |
| Project start | March 16, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $578,887 |
| NIH project number | 5R01AI175134-03 |
| Project ID | NIH-11021016 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living in malaria-endemic areas, particularly those who have been exposed to Plasmodium vivax.
✕Less likely to help
Patients who do not reside in malaria-endemic regions or those who have never been exposed to Plasmodium vivax may not benefit from this research.
What this research studies
This research investigates the genetic and immune factors that contribute to protection against Plasmodium vivax malaria, a significant health issue in endemic regions. By studying individuals in Cambodia who show remarkable clinical protection, the research aims to identify the mechanisms that lead to the production of protective antibodies. The approach includes analyzing immune responses and genetic profiles to uncover how some people can resist malaria despite exposure. This knowledge could inform the development of targeted interventions to prevent malaria.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing Plasmodium vivax malaria, potentially saving lives and reducing disease burden.
How similar studies have gone: While the specific mechanisms of protection against Plasmodium vivax are not well understood, similar research approaches have shown promise in understanding immune responses to other malaria species.
Where this research is happening
-
Institut Pasteur Du Cambodge
Phnom Penh, Cambodia Active
Researchers
- Principal investigator: Popovici, Jean — Institut Pasteur Du Cambodge
- Study coordinator: Popovici, Jean
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.