Understanding genetic and environmental factors affecting kidney disease in racial and ethnic minorities
Elucidating Genetic and Environmental Second Hits in Racial and Ethnic Minorities with APOL1 High-Risk Genotypes
This study is looking at how certain genes and environmental factors affect kidney disease in African Americans and Afro-Caribbean Hispanic Americans, aiming to find out what else might increase the risk for those already at higher risk, so we can improve prevention and treatment options for these communities.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11015051 on NIH RePORTER |
What this research studies
This research investigates how genetic factors, specifically the APOL1 gene variants, and environmental influences contribute to kidney disease disparities among African Americans and Afro-Caribbean Hispanic Americans. The study aims to identify additional genetic or environmental 'second hits' that may trigger kidney disease in individuals with high-risk APOL1 genotypes. By analyzing a diverse population, the research seeks to uncover the complex interactions that lead to kidney disease, which may help improve prevention and treatment strategies. The findings could lead to better clinical practices, including genetic testing and targeted therapies for at-risk populations.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals of African ancestry, particularly those with APOL1 high-risk genotypes.
Not a fit: Patients without APOL1 high-risk genotypes or those not of African ancestry may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of kidney disease in racial and ethnic minorities, ultimately enhancing patient outcomes.
How similar studies have performed: Previous research has shown promising results in understanding genetic factors in kidney disease, but this study aims to explore novel environmental interactions, making it a potentially groundbreaking approach.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Nadkarni, Girish Nitin — Icahn School of Medicine at Mount Sinai
- Study coordinator: Nadkarni, Girish Nitin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.