Understanding genetic and brain factors that predict cognitive decline in Alzheimer's disease.
Integrating Genetic, Neuroimaging, Transcriptomic, and Clinical Risk Factors as Multivariate Predictors of Cognitive Deterioration in Alzheimer's Disease.
This study is looking at how genes and brain scans can help us understand why some people with a high risk of Alzheimer's disease stay mentally sharp while others don’t, using a new method that analyzes blood samples to find clues about brain health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Upstate Medical University NIH-funded |
| Lab location | 1 site (Syracuse, United States) |
| Project ID | NIH-10883580 on NIH RePORTER |
What this research studies
This research investigates how genetic, neuroimaging, and clinical factors can predict cognitive deterioration in Alzheimer's disease (AD). By using a novel method called BrainGENIE, researchers aim to analyze blood samples to understand brain gene expression and its relationship to cognitive health. The study focuses on identifying risk factors that contribute to cognitive decline, particularly in individuals who are at high risk for AD but remain cognitively normal. This comprehensive approach could lead to new insights into resilience against Alzheimer's and improve early detection strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at high genetic risk for Alzheimer's disease who are currently cognitively normal.
Not a fit: Patients who are already experiencing significant cognitive decline or have a confirmed diagnosis of Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prediction and prevention strategies for cognitive decline in Alzheimer's disease.
How similar studies have performed: Other research has shown promise in using genetic and neuroimaging data to predict cognitive decline, suggesting that this approach could yield valuable insights.
Where this research is happening
Syracuse, United States
- Upstate Medical University — Syracuse, United States (Active)
Researchers
- Principal investigator: Hess, Jonathan — Upstate Medical University
- Study coordinator: Hess, Jonathan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.