Understanding genes that help develop rotator cuff tissue
Driver Genes for Engineered Rotator Cuff Development
['FUNDING_R01'] · PURDUE UNIVERSITY · NIH-10594580
This study is looking at how genes affect the creation of new shoulder tissue to help heal injuries, especially in the commonly hurt supraspinatus tendon, so that patients can recover faster and have better results from surgery.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PURDUE UNIVERSITY (nih funded) |
| Locations | 1 site (WEST LAFAYETTE, UNITED STATES) |
| Trial ID | NIH-10594580 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic factors that influence the development of engineered rotator cuff tissue, which is crucial for repairing shoulder injuries. The approach involves using advanced scaffolding techniques that mimic the natural structure of the rotator cuff tendons and testing these with stem cells derived from fat tissue. By focusing on the supraspinatus tendon, the most commonly injured tendon in the rotator cuff, the research aims to enhance tendon regeneration and reduce the risk of re-injury. Patients may benefit from improved surgical outcomes and faster recovery times if successful.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have suffered from rotator cuff injuries or tears.
Not a fit: Patients with chronic rotator cuff injuries that have not responded to previous treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for rotator cuff injuries, improving recovery and reducing the likelihood of re-tears.
How similar studies have performed: Previous research in tendon tissue engineering has shown promising results, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
WEST LAFAYETTE, UNITED STATES
- PURDUE UNIVERSITY — WEST LAFAYETTE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LITTLE, DIANNE — PURDUE UNIVERSITY
- Study coordinator: LITTLE, DIANNE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.