Understanding genes that affect bone density
Causal Genes at BMD Loci
['FUNDING_R01'] · UNIVERSITY OF WASHINGTON · NIH-11084365
This study is looking at how certain genes might affect bone strength in people with osteoporosis, using zebrafish to help find new ways to improve treatments for this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-11084365 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic factors that contribute to osteoporosis, a condition that weakens bones and increases fracture risk. By utilizing advanced techniques in zebrafish, the study aims to identify specific genes associated with bone mineral density (BMD) and understand how these genes influence bone health. The approach involves high-throughput biology to explore the functions of candidate genes located near identified genetic loci related to BMD. This could lead to the discovery of new therapeutic targets for osteoporosis treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for osteoporosis, particularly those with a family history of the condition or other genetic predispositions.
Not a fit: Patients who do not have osteoporosis or related bone density issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve bone density and reduce the risk of fractures in patients with osteoporosis.
How similar studies have performed: Previous research has shown success in identifying genetic factors related to bone density, suggesting that this approach could yield valuable insights.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KWON, RONALD Y — UNIVERSITY OF WASHINGTON
- Study coordinator: KWON, RONALD Y
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.