Understanding Genes in Kidney Diseases
Regulation of Kidney-Specific Gene Expression
This project helps us learn how a specific gene, HNF-1β, works in the kidneys and how changes in this gene can lead to various kidney problems like cysts.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-11175359 on NIH RePORTER |
What this research studies
Our kidneys rely on specific genes to work correctly, and sometimes changes in these genes can cause serious conditions. This project focuses on a key gene called HNF-1β, which is important for kidney development and function. When HNF-1β doesn't work right, it can lead to conditions like cystic kidney disease and other kidney and urinary tract issues. We are using special mouse models that show similar kidney problems to humans to understand exactly how HNF-1β controls other genes and pathways in the kidney. By studying these genetic networks, we hope to uncover the root causes of these inherited kidney diseases.
Who could benefit from this research
Good fit: Patients with inherited kidney diseases, such as cystic kidney disease or congenital anomalies of the kidney and urinary tract, could potentially benefit from future treatments developed from this foundational knowledge.
Not a fit: Patients whose kidney conditions are not related to genetic mutations in HNF-1β may not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of the genetic causes of inherited kidney diseases, paving the way for new ways to prevent or treat these conditions.
How similar studies have performed: This is a renewal of an ongoing project, building on previous successful work that identified key genetic networks and roles of HNF-1β in kidney function and disease.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Igarashi, Peter — State University New York Stony Brook
- Study coordinator: Igarashi, Peter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.