Understanding genes and lifestyle in heart and metabolic conditions
Genetic investigations of cardiometabolic disease: pleiotropy, gene x environment and causal inference analyses
This project explores how our genes and daily habits work together to influence conditions like type 2 diabetes, heart disease, and stroke.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11158599 on NIH RePORTER |
What this research studies
This grant aims to understand why conditions like heart disease, stroke, type 2 diabetes, and high blood pressure often occur together and share risk factors. Researchers are looking at the genetic makeup of over a million people from different backgrounds to see how genes interact with lifestyle factors like diet and alcohol. By examining these connections, they hope to identify different types of these conditions and better understand what causes them. This deeper understanding could lead to more personalized ways to prevent and treat these common health issues.
Who could benefit from this research
Good fit: This research uses existing data from a large number of adults, including those with adult-onset diabetes, abdominal obesity, and various ancestries, so direct patient recruitment for this specific grant is unlikely.
Not a fit: Patients not interested in understanding the genetic and environmental factors contributing to cardiometabolic diseases may not directly benefit from this foundational research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to identify individuals at higher risk for cardiometabolic diseases and develop more targeted prevention and treatment strategies.
How similar studies have performed: Genetic studies have successfully identified risk factors for various diseases, but this project's large scale and focus on pleiotropy and gene-environment interactions offer a novel approach to understanding cardiometabolic disease subtypes.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Salem, Rany — University of California, San Diego
- Study coordinator: Salem, Rany
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.