Understanding gene regulation in airway cells to find new treatments for lung diseases
Airway epithelial cell gene regulation: new mechanisms and therapeutic strategies
This study is looking at how changes in the genes of airway cells can impact lung health, especially for people with asthma, and aims to find new ways to help improve breathing.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11076295 on NIH RePORTER |
What this research studies
This research investigates how gene regulation in airway epithelial cells affects lung health, particularly in conditions like asthma. By using advanced techniques such as single cell RNA sequencing and CRISPR gene editing, the team aims to uncover the molecular mechanisms that lead to airway obstruction. The study focuses on human airway cells to provide insights that are directly applicable to patient care. Through this work, researchers hope to identify new therapeutic strategies to improve lung function.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with asthma or other airway diseases who are experiencing airflow limitation.
Not a fit: Patients with non-respiratory conditions or those without airway diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that alleviate symptoms and improve the quality of life for patients with asthma and other airway diseases.
How similar studies have performed: Previous research using similar methodologies has shown promise in understanding airway diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Erle, David J — University of California, San Francisco
- Study coordinator: Erle, David J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.