Understanding gene-regulating condensates in multiple myeloma
Project 2: Investigating regulation of transcriptional condensates in multiple myeloma
This project looks at how small clumps of gene-regulating molecules affect multiple myeloma cells to point toward new treatment ideas for people with the disease.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11389122 on NIH RePORTER |
What this research studies
Researchers are studying how transcriptional condensates—tiny assemblies of proteins and RNA that control gene activity—work in multiple myeloma cells. They combine experiments in the lab with analysis of patient-derived samples to see which condensates drive cancer growth. The team uses molecular tools to change condensate behavior and measures how myeloma cells respond. Findings may guide development of drugs that target these gene-regulating structures.
Who could benefit from this research
Good fit: Ideal participants would be people with multiple myeloma who can provide clinical samples (for example bone marrow or tumor material) or who receive care at Dana-Farber or its partner clinics.
Not a fit: People without multiple myeloma or those seeking immediate changes to their treatment are unlikely to get direct benefit from this basic-science work.
Why it matters
Potential benefit: If successful, this work could reveal new molecular targets and lead to therapies that more precisely stop myeloma cell growth.
How similar studies have performed: Targeting transcriptional condensates is a relatively new approach with promising laboratory results but limited clinical proof so far.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: Young, Richard — Dana-Farber Cancer Inst
- Study coordinator: Young, Richard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.