Understanding gene expression in the thalamus related to psychiatric disorders
Transcriptional diversity of human mediodorsal thalamus and its role in psychiatric disease
This study is looking at how differences in our genes might affect a part of the brain connected to schizophrenia and bipolar disorder, using brain samples to find out more about how these conditions work, which could help improve treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10448154 on NIH RePORTER |
What this research studies
This research investigates how genetic variations affect the functioning of the mediodorsal thalamus, a brain region linked to schizophrenia and bipolar disorder. By analyzing post-mortem brain samples, the study aims to uncover transcriptional differences that may contribute to the connectivity issues observed in these conditions. The approach utilizes advanced genomic technologies to examine gene expression at a single-cell level, providing insights into the biological mechanisms underlying these psychiatric diseases. Patients may benefit from a deeper understanding of their conditions and potential new treatment targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with schizophrenia or bipolar disorder, particularly those who have not responded well to current treatments.
Not a fit: Patients with psychiatric disorders not related to schizophrenia or bipolar disorder may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for schizophrenia and bipolar disorder by identifying new biological targets.
How similar studies have performed: Previous research has shown promising results in understanding the genetic basis of psychiatric disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC — New York, United States (Active)
Researchers
- Principal investigator: Schulmann, Anton — New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC
- Study coordinator: Schulmann, Anton
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.