Understanding gene expression in pediatric tissues
Official title: Pediatric Biospecimen Procurement Center (BPC) Supporting the Developmental Gene Expression (dGTEx) Project
Funded at National Disease Research Interchange · NIH-10685487 · Data updated 2026-11-12
This study is looking to gather important information about how genes work in different types of tissues from children at various ages, which will help us understand growth and development better, while also making sure we handle tissue donations ethically.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | National Disease Research Interchange NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 9, 2021 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $2,343,364 |
| NIH project number | 5U24HD106537-03 |
| Project ID | NIH-10685487 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation include children from birth to 21 years old who are undergoing medical procedures that require tissue samples.
✕Less likely to help
Patients who are adults or those who do not require tissue sampling for medical reasons may not benefit from this research.
What this research studies
This research aims to create a comprehensive resource that links gene expression and genetic variation in pediatric tissues from various organ systems. It will analyze around 30 different tissue types across four developmental stages: early post-natal, early childhood, pre-pubertal, and post-pubertal. The project will utilize advanced methodologies, including single-cell analysis, to provide detailed insights into the developing brain and other tissues. Additionally, it will address ethical considerations surrounding pediatric tissue donation, ensuring a holistic approach to the research.
Why it matters
Potential benefit: If successful, this research could lead to significant advancements in understanding pediatric health and disease, ultimately improving treatment options for children.
How similar studies have gone: Other research initiatives focusing on gene expression in pediatric populations have shown promise, indicating that this approach could yield valuable insights.
Where this research is happening
-
National Disease Research Interchange
Philadelphia, United States Active
Researchers
- Principal investigator: Bell, Thomas J — National Disease Research Interchange
- Study coordinator: Bell, Thomas J
Related research
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Pediatric tissue bank to map gene activity during growth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.