Understanding Gene Control Networks in Single Cells
Integrated frameworks for single-cell epigenomics based transcriptional regulatory networks
This project aims to better understand how genes are turned on and off in individual cells, which is important for how our bodies develop and function.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project ID | NIH-11139555 on NIH RePORTER |
What this research studies
Our bodies rely on special proteins called transcription factors to control which genes are active in different cells and tissues. When this control goes wrong, it can lead to many complex diseases. This work focuses on building new ways to map these gene control networks at a very detailed level, looking at individual cells. Current methods struggle to capture the full picture of how these networks change over time and how they are affected by the 3D structure of our DNA, so this project seeks to create better tools for a clearer understanding.
Who could benefit from this research
Good fit: This foundational work does not directly involve patients, but future studies building on these insights may seek individuals with diseases linked to gene regulation issues.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not find direct benefit from this basic science project.
Why it matters
Potential benefit: A deeper understanding of how genes are regulated could eventually lead to new ways to prevent or treat diseases caused by faulty gene control.
How similar studies have performed: While the concept of gene regulation is well-established, this project proposes novel computational frameworks to analyze these complex networks at single-cell resolution, building on existing but limited approaches.
Where this research is happening
Hershey, United States
- Pennsylvania State Univ Hershey Med Ctr — Hershey, United States (Active)
Researchers
- Principal investigator: Uzun, Yasin — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Uzun, Yasin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.