Understanding gene control in lens development to prevent cataracts
Official title: Transcriptional control of gene expression in the lens
Funded at University of Delaware · NIH-11027252 · Data updated 2026-11-12
This study is looking at how certain proteins, called Mafg and Mafk, help the eye lens develop and stay clear, which could help us understand and find new ways to treat cataracts.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Delaware NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $386,676 |
| NIH project number | 1R01EY036923-01 |
| Project ID | NIH-11027252 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk of developing cataracts, particularly those with a family history of lens developmental defects.
✕Less likely to help
Patients who already have advanced cataracts or other unrelated eye conditions may not benefit from this research.
What this research studies
This research investigates the role of specific transcription factors, Mafg and Mafk, in the development of the eye lens and their connection to cataract formation. By utilizing a bioinformatics tool called iSyTE, the study aims to identify the proteins and mechanisms that regulate lens transparency and development. The researchers will analyze genetically modified mice to observe how changes in these transcription factors affect lens structure and function, providing insights into potential therapeutic targets for cataracts.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cataracts, potentially improving vision and quality of life for patients.
How similar studies have gone: Previous research has shown promising results in understanding gene regulation in lens development, indicating that this approach could yield valuable insights.
Where this research is happening
-
University of Delaware
Newark, United States Active
Researchers
- Principal investigator: Lachke, Salil — University of Delaware
- Study coordinator: Lachke, Salil
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.