Understanding gene changes in joint tissue related to arthritis
Using high dimensional molecular data to decipher gene dynamics underlying pathogenic synovial fibroblasts
This study is looking at certain cells in your joints that play a role in diseases like rheumatoid arthritis and osteoarthritis, to learn how they change over time and find new ways to treat these conditions.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11064794 on NIH RePORTER |
What this research studies
This research investigates the behavior of specific cells called synovial fibroblasts that contribute to joint diseases like rheumatoid arthritis and osteoarthritis. By using advanced techniques such as single cell RNA sequencing, the study aims to identify different types of these fibroblasts and how they change over time in the body. The researchers will analyze samples from patients to understand the genes involved in these changes, which could lead to new treatment strategies. The goal is to better understand how these cells drive disease progression and how they might be targeted with therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with rheumatoid arthritis or osteoarthritis who are undergoing treatment.
Not a fit: Patients with joint diseases not related to rheumatoid arthritis or osteoarthritis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that specifically target the harmful cells in arthritis, improving treatment outcomes for patients.
How similar studies have performed: Previous research has shown promising results in understanding cell behavior in arthritis, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Korsunskiy, Ilya — Brigham and Women's Hospital
- Study coordinator: Korsunskiy, Ilya
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.