Understanding gene changes in Alzheimer's disease and related dementias
Official title: Identifying genetically driven gene dysregulation in Alzheimer's disease and related dementias using statistical data integration
Funded at Icahn School of Medicine at Mount Sinai · NIH-11001234 · Data updated 2026-11-12
This study is looking at how our genes might affect the way certain genes behave in Alzheimer's disease and similar conditions, with the hope that understanding these genetic links can help find new ways to treat patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $603,742 |
| NIH project number | 5R01AG078657-03 |
| Project ID | NIH-11001234 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or related dementias, as well as those at risk due to genetic factors.
✕Less likely to help
Patients with non-genetic forms of dementia or those without a family history of Alzheimer's may not benefit from this research.
What this research studies
This research investigates how genetic factors contribute to the dysregulation of genes in Alzheimer's disease and related dementias. By integrating various types of molecular data, including transcriptomes and proteomes, the study aims to identify key genes associated with these conditions. Patients may benefit from this research as it seeks to uncover the genetic underpinnings of Alzheimer's, potentially leading to new therapeutic targets. The approach involves advanced statistical methods and the use of extensive genomic datasets to enhance the understanding of these complex disorders.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic causes of Alzheimer's disease, paving the way for innovative treatments.
How similar studies have gone: Previous research has shown promise in using multiomics approaches to understand complex diseases, suggesting that this methodology could yield significant insights.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Voloudakis, Georgios — Icahn School of Medicine at Mount Sinai
- Study coordinator: Voloudakis, Georgios
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.