Understanding Gene Activity Changes in Esophageal Cancer
Official title: Disruption of Transcription Networks in Esophageal Adenocarcinoma Tumorigenesis
Funded at University of Miami School of Medicine · NIH-11127388 · Data updated 2026-11-12
This research explores how acid reflux can lead to esophageal cancer by changing gene activity, hoping to find new ways to treat this condition.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | July 8, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $1,544,026 |
| NIH project number | 5P01CA268991-04 |
| Project ID | NIH-11127388 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with esophageal adenocarcinoma or Barrett's esophagus, a pre-cancerous condition, are the ultimate focus of this research, though direct participation in this specific grant may involve tissue donation rather than clinical trials.
✕Less likely to help
Patients without esophageal adenocarcinoma or Barrett's esophagus would not directly benefit from this specific research.
What this research studies
Esophageal adenocarcinoma is a serious cancer that has become more common, and we need better treatments. This project aims to understand how chronic acid reflux, a common issue, can cause this cancer by changing how genes work. Researchers are looking at specific protein interactions that promote cancer cell survival and growth. They will use advanced lab models, animal models, and human tissue samples to uncover these processes and test potential new therapies.
Why it matters
Potential benefit: If successful, this work could lead to new treatments for esophageal adenocarcinoma by targeting the specific molecular changes that drive the disease.
How similar studies have gone: This program builds on existing knowledge of cancer biology and reflux disease, exploring novel molecular pathways that contribute to esophageal cancer development.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: El-Rifai, Wael — University of Miami School of Medicine
- Study coordinator: El-Rifai, Wael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.