Understanding Foot Problems in Diabetes and Kidney Disease
Chronic Kidney Disease-Mineral Bone Disorder (CKD-MBD) Syndrome in the Diabetic, Neuropathic Foot
This project looks at how kidney disease affects foot bone and blood vessel problems in people with diabetes to help prevent amputations.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11124181 on NIH RePORTER |
What this research studies
People with diabetes and nerve damage in their feet are at high risk for serious foot problems, including amputations. Our previous work showed that issues with foot bones and blood vessels contribute to these problems. However, we don't fully understand why people with both diabetes and advanced kidney disease have the highest risk. This project aims to discover if a condition called CKD-mineral bone disorder (CKD-MBD) is the missing piece, making foot bones weaker and blood vessels harder. We are studying people with Type 2 diabetes and nerve damage across different stages of kidney disease to understand this connection better.
Who could benefit from this research
Good fit: Ideal candidates for this type of research would be individuals with Type 2 diabetes, peripheral neuropathy, and varying stages of chronic kidney disease.
Not a fit: Patients without diabetic peripheral neuropathy or chronic kidney disease would likely not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to identify and treat people at highest risk for foot amputations, improving their quality of life.
How similar studies have performed: Previous research has identified a link between foot bone and vascular deterioration and amputation risk in diabetic peripheral neuropathy, but the specific role of CKD-MBD in the foot is a novel area of focus.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Hastings, Mary K — Washington University
- Study coordinator: Hastings, Mary K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.