Understanding FGF21's role in Duchenne Muscular Dystrophy bone health
Role of FGF21 in DMD
['FUNDING_R01'] · UNIVERSITY OF IOWA · NIH-11163511
This project explores how a specific protein called FGF21 contributes to bone problems in children with Duchenne Muscular Dystrophy.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF IOWA (nih funded) |
| Locations | 1 site (IOWA CITY, UNITED STATES) |
| Trial ID | NIH-11163511 on ClinicalTrials.gov |
What this research studies
Duchenne Muscular Dystrophy (DMD) affects both muscles and bones in children, and we don't fully understand why bone health is poor or how to treat it. Researchers have found a protein, FGF21, that is much higher in the muscles of DMD mouse models than in healthy muscles. This project aims to discover where this extra FGF21 comes from and how it harms bones in DMD. By studying mouse models and cells, we hope to uncover the exact ways FGF21 affects muscle, bone, and overall body health.
Who could benefit from this research
Good fit: This foundational research is relevant for children diagnosed with Duchenne Muscular Dystrophy, particularly those experiencing bone health issues.
Not a fit: Patients without Duchenne Muscular Dystrophy or those not experiencing bone complications related to the condition may not directly benefit from this specific line of inquiry.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that slow or stop bone weakening and fractures in children with Duchenne Muscular Dystrophy.
How similar studies have performed: This approach investigates a novel protein, FGF21, in the context of DMD bone health, representing a new and untested area of focus.
Where this research is happening
IOWA CITY, UNITED STATES
- UNIVERSITY OF IOWA — IOWA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LI, HONGSHUAI — UNIVERSITY OF IOWA
- Study coordinator: LI, HONGSHUAI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.