Understanding fatigue in people recovering from COVID-19
Neural Mechanisms of Fatigue in Post-Acute Sequela of SARS-CoV-2
['FUNDING_R01'] · HUGO W. MOSER RES INST KENNEDY KRIEGER · NIH-11023203
This study is looking at how COVID-19 might affect your nervous system and cause ongoing fatigue after recovery, and it's for anyone who has been feeling unusually tired after their COVID-19 illness.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HUGO W. MOSER RES INST KENNEDY KRIEGER (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-11023203 on ClinicalTrials.gov |
What this research studies
This research investigates how COVID-19 affects the nervous system, particularly focusing on the persistent fatigue experienced by some individuals after recovery, known as Post-Acute Sequelae of SARS-CoV-2 Infection (PASC). The study aims to explore the relationship between blood-brain barrier (BBB) dysfunction and feelings of fatigue through a combination of human participant experiments, neuroimaging, and computational modeling. By examining how COVID-19 may alter brain function and effort perception, the research seeks to uncover the underlying neural mechanisms contributing to fatigue in these patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced COVID-19 and are suffering from persistent fatigue or other neurological symptoms.
Not a fit: Patients who have not had COVID-19 or do not experience fatigue as a symptom may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for fatigue in individuals recovering from COVID-19.
How similar studies have performed: While the specific relationship between BBB dysfunction and fatigue in PASC is novel, related research has shown that neuroinflammation plays a significant role in fatigue in other neurological disorders.
Where this research is happening
BALTIMORE, UNITED STATES
- HUGO W. MOSER RES INST KENNEDY KRIEGER — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHIB, VIKRAM S — HUGO W. MOSER RES INST KENNEDY KRIEGER
- Study coordinator: CHIB, VIKRAM S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adverse sequelae of coronavirus disease, adverse sequelae of coronavirus disease 2019