Understanding fatigue in older adults
Neural and Energetic Drivers of Performance and Perceived Fatigability in Older Adults
This study is looking at why older adults feel tired and how their brain and muscles work together, hoping to find ways to help them feel more energetic and improve their physical performance.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11095967 on NIH RePORTER |
What this research studies
This research investigates the causes of fatigue in older adults, focusing on how brain and muscle function contribute to physical performance. It aims to understand the role of neuro-energetic processes, particularly dopamine signaling and oxygen metabolism, in influencing fatigability. By examining these factors, the study seeks to identify potential interventions that could improve physical performance and reduce fatigue in older individuals. Participants will undergo assessments to measure their physical performance and related biological markers.
Who could benefit from this research
Good fit: Ideal candidates for this research are community-dwelling adults aged 65 and older who experience higher levels of fatigue.
Not a fit: Patients under the age of 65 or those with specific medical conditions that severely limit their physical capabilities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for reducing fatigue and improving physical performance in older adults.
How similar studies have performed: Previous research has shown promising results in younger adults regarding neuro-energetic interventions, but this approach in older adults is relatively novel and untested.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Rosano, Caterina — University of Pittsburgh at Pittsburgh
- Study coordinator: Rosano, Caterina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.