Understanding fat loss mechanisms in a genetic disorder affecting metabolism
Mechanisms of adipocyte loss in laminopathy-induced lipodystrophy in mice and humans
This study is looking at how a genetic change affects fat cells and causes lipodystrophy, which leads to fat loss and problems like diabetes, and it's for people who want to understand more about this condition and find better treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10981538 on NIH RePORTER |
What this research studies
This research investigates how a genetic mutation affects fat cells, leading to a condition called lipodystrophy, which results in the loss of adipose tissue and related metabolic issues like diabetes. By studying both mice and human patients, the researchers aim to uncover the cellular and molecular processes that cause this fat loss, particularly during puberty. The study employs advanced mouse models to simulate the condition and analyze the role of specific proteins in maintaining healthy fat cells. Insights gained from this research could help develop targeted treatments for individuals suffering from this disorder.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with familial partial lipodystrophy type 2 (FPLD2) or those experiencing unexplained adipose tissue loss.
Not a fit: Patients without genetic mutations related to lipodystrophy or those with other unrelated metabolic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that help manage or reverse the metabolic complications associated with lipodystrophy.
How similar studies have performed: Previous research has shown promising results in understanding lipodystrophy mechanisms, but this specific approach using advanced mouse models is relatively novel.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Macdougald, Ormond a — University of Michigan at Ann Arbor
- Study coordinator: Macdougald, Ormond a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.