Understanding Fat Cell Stress in Diabetes
Adipose Tissue Metabolic Stress Responses
['FUNDING_R01'] · UNIV OF MASSACHUSETTS MED SCH WORCESTER · NIH-11123223
This research aims to understand how stress in fat cells contributes to obesity, insulin resistance, and type 2 diabetes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF MASSACHUSETTS MED SCH WORCESTER (nih funded) |
| Locations | 1 site (WORCESTER, UNITED STATES) |
| Trial ID | NIH-11123223 on ClinicalTrials.gov |
What this research studies
Obesity can lead to serious health problems like insulin resistance and type 2 diabetes. Our bodies' fat cells play a key role in this process, especially when they experience stress. This project looks closely at a specific signaling pathway, called JNK, within fat cells to discover how it causes inflammation and makes the body resistant to insulin. By understanding these detailed mechanisms, we hope to find new ways to help people manage or prevent these conditions.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation at this stage, but it focuses on understanding conditions relevant to individuals with obesity, insulin resistance, or type 2 diabetes.
Not a fit: Patients not affected by obesity, insulin resistance, or type 2 diabetes would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new targets for medicines that prevent or treat insulin resistance and type 2 diabetes by addressing stress in fat cells.
How similar studies have performed: Previous studies in mice have shown that blocking certain JNK signals in fat cells can prevent inflammation and insulin resistance, suggesting this is a promising area of investigation.
Where this research is happening
WORCESTER, UNITED STATES
- UNIV OF MASSACHUSETTS MED SCH WORCESTER — WORCESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DAVIS, ROGER J. — UNIV OF MASSACHUSETTS MED SCH WORCESTER
- Study coordinator: DAVIS, ROGER J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus