Understanding Fascin's Role in Alzheimer's Disease
Regulation of mitochondrial DNA homeostasis and neuroinflammation by Fascin in Alzheimer’s Disease
This project explores how a protein called Fascin might contribute to Alzheimer's disease by affecting energy production and inflammation in brain cells, aiming to find new ways to help people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lurie Children's Hospital of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-11297283 on NIH RePORTER |
What this research studies
Alzheimer's disease is a common brain disorder affecting many older adults, and we currently lack effective treatments. This work looks into a protein named Fascin, which we've found plays an unexpected role in how brain cells manage their energy and respond to stress. We believe that problems with Fascin could lead to inflammation and damage in the brain, contributing to Alzheimer's. By understanding these processes better, we hope to uncover new targets for future therapies.
Who could benefit from this research
Good fit: This foundational research is focused on understanding disease mechanisms and is not currently recruiting patients for direct participation.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention would not benefit from this basic science investigation.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of Alzheimer's disease and potentially identify new targets for developing much-needed treatments.
How similar studies have performed: This project explores a novel role for the Fascin protein in Alzheimer's disease, building on recent unexpected findings by the researchers.
Where this research is happening
Chicago, United States
- Lurie Children's Hospital of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Ma, Yongchao Charles — Lurie Children's Hospital of Chicago
- Study coordinator: Ma, Yongchao Charles
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.