Understanding fallopian tube cells that can lead to cancer
Cancer-prone cell states of the fallopian tubal epithelium
This project aims to understand specific cell types in the fallopian tubes that are more likely to develop into aggressive ovarian cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cornell University NIH-funded |
| Lab location | 1 site (Ithaca, United States) |
| Project ID | NIH-11077245 on NIH RePORTER |
What this research studies
High-grade serous carcinoma (HGSC) is a very aggressive type of ovarian cancer often found late, and it frequently starts in the fallopian tubes. Researchers are looking closely at the different kinds of cells found in the fallopian tubes to see which ones might be more prone to becoming cancerous. By using advanced techniques like single-cell analysis, they hope to map out how these cells are related and identify the specific features that make some cells more likely to develop into cancer. This work could help explain why some ovarian cancers behave differently and respond to treatments in various ways.
Who could benefit from this research
Good fit: This foundational research is relevant to patients at risk for or diagnosed with high-grade serous ovarian cancer, particularly those interested in the biological origins of their disease.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention will not receive direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to earlier detection methods and more targeted treatments for high-grade serous ovarian cancer by identifying the specific cells where it originates.
How similar studies have performed: This project builds upon recent advances in single-cell analysis and genomic studies that have begun to identify different cell types and genetic abnormalities in ovarian cancer.
Where this research is happening
Ithaca, United States
- Cornell University — Ithaca, United States (Active)
Researchers
- Principal investigator: Nikitin, Alexander Y. — Cornell University
- Study coordinator: Nikitin, Alexander Y.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.