Understanding factors that regulate von Willebrand Factor levels
Official title: Regulators of von Willebrand Factor Levels
Funded at University of North Texas · NIH-10666422 · Data updated 2026-11-12
This study is looking at how certain genes affect the amount of a protein called von Willebrand Factor, which is important for blood clotting, and it's designed for people interested in understanding conditions like von Willebrand disease and blood clotting issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of North Texas NIH-funded |
| Lab location | 1 site (Denton, United States) |
| Project start | August 1, 2021 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $297,000 |
| NIH project number | 5R01HL159399-03 |
| Project ID | NIH-10666422 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with von Willebrand disease or individuals with elevated VWF levels.
✕Less likely to help
Patients without any bleeding disorders or those not affected by VWF level abnormalities may not benefit from this research.
What this research studies
This research investigates the genetic factors that influence the levels of von Willebrand Factor (VWF), a crucial protein for blood clotting. By using a zebrafish model, researchers will identify genes that modify VWF levels, which can lead to conditions like von Willebrand disease (VWD) or increase the risk of thrombosis. The study employs advanced genetic techniques to knock down specific genes and observe their effects on VWF regulation. This approach aims to fill the knowledge gap regarding the genetic modifiers of VWF levels, which is essential for developing targeted treatments.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with bleeding disorders and those at risk of thrombosis.
How similar studies have gone: Previous research has successfully identified genetic factors influencing blood coagulation, suggesting potential for success in this novel approach.
Where this research is happening
-
University of North Texas
Denton, United States Active
Researchers
- Principal investigator: Jagadeeswaran, Pudur — University of North Texas
- Study coordinator: Jagadeeswaran, Pudur
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.