Understanding factors that make people susceptible to Candida auris infections.
Host factors affecting susceptibility to Candida auris.
This study is looking at how certain changes in our body's natural defenses and bacteria can make older adults and people with weakened immune systems more likely to get infections from a tough fungus called Candida auris, with the goal of finding better ways to prevent and treat these infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louis Stokes Cleveland VA Medical Center NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10767794 on NIH RePORTER |
What this research studies
This research investigates the host factors that contribute to infections caused by Candida auris, a multi-drug resistant fungal pathogen. It focuses on how changes in the body's microbiota or immune system can lead to increased vulnerability to these infections, particularly in older adults and those with weakened immune systems. The study aims to identify specific characteristics that may predispose individuals to mucosal infections, which can escalate to more severe bloodstream infections. By analyzing patient data and infection patterns, the research seeks to improve prevention and treatment strategies for those at risk.
Who could benefit from this research
Good fit: Ideal candidates for this research include elderly individuals, immunocompromised patients, and those receiving care in healthcare settings.
Not a fit: Patients who are young, healthy, and have no underlying health conditions are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment options for patients at risk of Candida auris infections.
How similar studies have performed: Previous research has shown success in understanding host-pathogen interactions in fungal infections, indicating that this approach may yield valuable insights.
Where this research is happening
Cleveland, United States
- Louis Stokes Cleveland VA Medical Center — Cleveland, United States (Active)
Researchers
- Principal investigator: Hise, Amy G — Louis Stokes Cleveland VA Medical Center
- Study coordinator: Hise, Amy G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.