Understanding factors that influence early pregnancy success
Official title: Immunological, epigenetic and developmental determinants of early pregnancy success
Funded at University of California, San Francisco · NIH-11193637 · Data updated 2026-11-12
This study is looking at how certain immune and genetic factors in the uterus can influence the success of early pregnancy, helping us understand why some pregnancies don't work out and how inflammation might play a role, with the hope of finding better ways to support women facing early pregnancy challenges.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | January 1, 2025 |
| Project end | April 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $132,338 |
| NIH project number | 3P50HD112034-02S1 |
| Project ID | NIH-11193637 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women of childbearing age who have experienced difficulties in achieving or maintaining early pregnancy.
✕Less likely to help
Patients who are not of childbearing age or those who have no history of pregnancy complications may not receive direct benefits from this research.
What this research studies
This research investigates how certain immune and genetic factors in the uterus affect the success of early pregnancy. It focuses on the decidua, a tissue that supports the placenta and suppresses harmful inflammatory responses that could jeopardize pregnancy. By examining how these responses are regulated at the genetic level, the study aims to uncover why some pregnancies fail and how inflammation before implantation can impact pregnancy outcomes. Patients may benefit from insights that could lead to improved diagnostic and therapeutic strategies for early pregnancy complications.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and management of early pregnancy complications, potentially improving outcomes for women trying to conceive.
How similar studies have gone: Other research has shown promising results in understanding the role of immune responses in pregnancy, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Erlebacher, Adrian — University of California, San Francisco
- Study coordinator: Erlebacher, Adrian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.