Understanding factors that affect the timing of Alzheimer's disease symptoms
Official title: Multi-cohort study of factors that influence Alzheimer's disease biomarker and dementia timing
Funded at University of Wisconsin-Madison · NIH-10991689 · Data updated 2026-11-12
This study is looking at how different factors can help us understand when people who have early signs of Alzheimer's might start showing symptoms, so we can better predict their risk and find ways to help them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | February 1, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $693,664 |
| NIH project number | 5R01AG080766-03 |
| Project ID | NIH-10991689 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have detectable Alzheimer's biomarkers but do not yet exhibit cognitive symptoms.
✕Less likely to help
Patients who are already experiencing significant cognitive decline or have a confirmed diagnosis of Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates how various factors influence the timing of Alzheimer's disease symptoms in individuals who show early signs of the disease but do not yet have cognitive symptoms. By utilizing advanced imaging and fluid-based biomarkers, the study aims to identify when these individuals might develop dementia. The researchers have developed a method to estimate the age at which amyloid pathology begins, allowing them to create a timeline for Alzheimer's progression. This approach will help improve predictions for dementia risk and inform treatment strategies for those at risk.
Why it matters
Potential benefit: If successful, this research could lead to better predictions of when individuals with preclinical Alzheimer's will develop dementia, allowing for earlier interventions.
How similar studies have gone: Other research has shown promise in using biomarkers to predict Alzheimer's progression, making this approach a continuation of successful methodologies.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Betthauser, Tobey James — University of Wisconsin-Madison
- Study coordinator: Betthauser, Tobey James
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.