Understanding factors that affect the severity and survival of sickle cell disease
'Omics predictors of Sickle Cell Severity and Survival
This study is looking at how different biological factors affect the health and survival of people with sickle cell disease, especially those over 50, to help create better, personalized treatments for them.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-10983638 on NIH RePORTER |
What this research studies
This research investigates how various biological factors influence the severity of sickle cell disease (SCD) and the survival of patients, particularly those over the age of 50. By analyzing multi-omics data, which includes genetic, biochemical, and clinical information, the study aims to identify predictors of health outcomes in SCD patients. The goal is to enhance personalized care and treatment strategies for individuals living with this condition, especially as they age. The research will utilize data from a long-term follow-up of patients to better understand the relationship between these biological markers and patient health.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 50 and older who have been diagnosed with sickle cell disease.
Not a fit: Patients with sickle cell disease who are under the age of 50 may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved care strategies and potentially extend the life expectancy of patients with sickle cell disease.
How similar studies have performed: Previous research has shown promising results in using multi-omics approaches to understand complex diseases, suggesting that this method could be effective for sickle cell disease as well.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Ashley-Koch, Allison E — Duke University
- Study coordinator: Ashley-Koch, Allison E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.