Understanding factors affecting eosinophilic mucin chronic rhinosinusitis
Official title: Eosinophilic Mucin Chronic Rhinosinusitis: Determining the multi-level factors that mediate disease and disparities
Funded at University of Miami School of Medicine · NIH-11015857 · Data updated 2026-11-12
This study is looking at how different factors affect the treatment success for people with a tough type of chronic sinusitis called eosinophilic mucin chronic rhinosinusitis, especially focusing on Hispanic and Black patients, to create better treatment plans that work for everyone.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Miami School of Medicine NIH-funded |
| Lab location | 1 site (Coral Gables, United States) |
| Project start | July 7, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $154,440 |
| NIH project number | 5K23MD018458-03 |
| Project ID | NIH-11015857 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include Hispanic and Black patients diagnosed with eosinophilic mucin chronic rhinosinusitis.
✕Less likely to help
Patients with other forms of chronic rhinosinusitis or those not belonging to the targeted demographic groups may not benefit from this research.
What this research studies
This research investigates the complex factors that influence the treatment outcomes of eosinophilic mucin chronic rhinosinusitis (EMRS), a severe form of chronic sinusitis that disproportionately affects Hispanic and Black patients. The project aims to develop patient-centered treatment pathways by analyzing the disparities in disease presentation and outcomes among different populations. Through a structured training program, the principal investigator will work with mentors to gather evidence that can help predict treatment outcomes and reduce the burden of this debilitating condition. The research will involve a multidisciplinary approach to identify the biological and social determinants impacting patient care.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies and outcomes for patients suffering from eosinophilic mucin chronic rhinosinusitis.
How similar studies have gone: Previous research has indicated disparities in chronic rhinosinusitis outcomes among different populations, suggesting that this approach could yield meaningful insights.
Where this research is happening
-
University of Miami School of Medicine
Coral Gables, United States Active
Researchers
- Principal investigator: Levine, Corinna Gehrett — University of Miami School of Medicine
- Study coordinator: Levine, Corinna Gehrett
Related research
Other NIH-funded projects on the same topics.
-
Decoding how GAA repeats in FGF14 cause SCA27B
This project looks at why a specific DNA repeat in the FGF14 gene leads to Spinocerebellar Ataxia 27B in adults.
-
Breathing therapy to help clear brain toxins in older adults who sleep poorly
A small study will test a breathing-based therapy to boost brain toxin clearance in older adults with poor sleep patterns related to Alzheimer’s risk.
-
New retinal imaging to detect brain small vessel disease
A fast, wide-field eye imaging method will measure how tiny retinal blood vessels rhythmically flow to help detect early brain small vessel disease.
-
Understanding the Genetics Behind IBD in South Florida
This grant looks at how genes and the environment come together to influence inflammatory bowel disease in people living in South Florida.
-
MorpHiC Data Resource and Coordinating Center
A national effort to build and share a comprehensive, high-quality catalogue of how human genes affect cell function when they’re turned off, using human cellular models.
-
MorPhiC data hub for gene function in human cells
A data resource and coordinating center will organize and share information about how human genes affect cellular traits when knocked out, helping researchers understand gene functions.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.