Understanding facial development issues and their genetic causes
Official title: Genetic, Tissue, and Anatomical Interactions in Mandibulofacial Dysmorphogenesis
Funded at Mayo Clinic Rochester · NIH-11093618 · Data updated 2026-11-12
This study is looking at how certain genes and development processes can cause facial differences, like mandibulofacial dysostosis, using mice to help us understand what happens during important growth stages, with the hope of improving diagnosis and treatment for people with these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $713,426 |
| NIH project number | 7R01DE029832-04 |
| Project ID | NIH-11093618 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with diagnosed mandibulofacial dysostosis or related facial anomalies.
✕Less likely to help
Patients with facial anomalies not related to genetic or developmental factors may not benefit from this research.
What this research studies
This research investigates the genetic and developmental processes that lead to facial anomalies, particularly focusing on conditions like mandibulofacial dysostosis. By using mouse models, the study aims to uncover the molecular interactions and anatomical changes that occur during critical stages of development. This approach allows researchers to analyze the underlying causes of these conditions, which are often difficult to study in humans due to ethical and practical limitations. The findings could lead to better diagnostic tools and treatment strategies for affected individuals.
Why it matters
Potential benefit: If successful, this research could improve the understanding and treatment of facial anomalies, potentially leading to better outcomes for patients requiring corrective surgery.
How similar studies have gone: Previous research has shown success in using animal models to understand genetic causes of developmental anomalies, indicating that this approach is promising.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Jabs, Ethylin Wang — Mayo Clinic Rochester
- Study coordinator: Jabs, Ethylin Wang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.