Understanding Eye Pressure Regulation in Glaucoma
Modulation of Outflow Facility and Biomechanics
['FUNDING_R01'] · OREGON HEALTH & SCIENCE UNIVERSITY · NIH-11094796
This work explores how different treatments affect the eye's natural fluid drainage system to better manage glaucoma, a condition that can lead to blindness.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON HEALTH & SCIENCE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-11094796 on ClinicalTrials.gov |
What this research studies
Glaucoma is a major cause of irreversible blindness, often linked to high pressure inside the eye. This pressure is controlled by a delicate balance of fluid production and drainage through specific tissues in the eye. We want to understand how these drainage tissues behave in both healthy eyes and those with glaucoma, especially how they respond to different medications. By using advanced imaging and computer models, we aim to uncover the exact ways treatments change eye fluid drainage. This knowledge could help us find new ways to diagnose and treat glaucoma more effectively.
Who could benefit from this research
Good fit: This foundational work is for patients interested in the underlying causes of glaucoma and the development of future therapies, rather than direct participation in a clinical trial.
Not a fit: Patients seeking immediate new treatments or direct clinical intervention would not directly benefit from this basic science investigation.
Why it matters
Potential benefit: If successful, this work could lead to new ways to diagnose glaucoma earlier and develop more effective treatments to preserve vision.
How similar studies have performed: While the specific combination of advanced imaging and inverse finite element methods is innovative, research into the biomechanics of ocular outflow tissues has been ongoing, with some success in identifying key mechanisms.
Where this research is happening
PORTLAND, UNITED STATES
- OREGON HEALTH & SCIENCE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KARIMI, ALIREZA — OREGON HEALTH & SCIENCE UNIVERSITY
- Study coordinator: KARIMI, ALIREZA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.