Understanding eye development and diseases using mouse models
Optic Stalk-Disc Development and Differentiation
This study is looking at how certain genes might cause eye diseases by experimenting with mice, which could help us understand conditions like aniridia and anophthalmia, and hopefully lead to new treatments for people affected by these vision problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-10878954 on NIH RePORTER |
What this research studies
This research investigates the causes of human eye diseases by studying mouse models. It employs advanced genetic techniques and various laboratory methods to explore how specific genes influence the development of eye structures and the differentiation of supporting cells in the eye. By manipulating genes in mice, researchers aim to uncover the mechanisms that lead to conditions like aniridia and anophthalmia, which can affect vision. The findings could provide insights into potential treatments for these ocular diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals under 21 years old with congenital eye disorders such as aniridia or anophthalmia.
Not a fit: Patients with acquired eye diseases unrelated to genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating serious eye conditions in humans.
How similar studies have performed: Previous research using similar genetic approaches in animal models has shown promise in understanding and potentially treating genetic eye disorders.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Brown, Nadean L — University of California at Davis
- Study coordinator: Brown, Nadean L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.