Understanding extra chromosomes and their link to health issues
Investigating supernumerary chromosome biology using the B chromosome model system
This work explores how extra, nonessential chromosomes form and behave, which can help us understand conditions like developmental disorders and cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Storrs NIH-funded |
| Lab location | 1 site (Storrs-Mansfield, United States) |
| Project ID | NIH-11126002 on NIH RePORTER |
What this research studies
Our bodies rely on a specific number of chromosomes for normal health, but sometimes extra chromosomes appear, leading to conditions like developmental disorders, infertility, and cancer. We don't fully understand why these extra chromosomes arise or how they affect health. This project uses a special fruit fly model system to learn more about these extra chromosomes. By studying fruit flies, we hope to uncover the genetic reasons behind these extra chromosomes and how they impact human health.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit individuals affected by conditions linked to extra chromosomes, such as certain cancers or developmental disorders.
Not a fit: Patients not affected by conditions related to extra chromosomes or aneuploidy may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of the causes of developmental disorders, infertility, and cancer, potentially guiding future prevention or treatment strategies.
How similar studies have performed: This project utilizes a newly established model system, representing a novel approach to investigate previously understudied aspects of supernumerary chromosome biology.
Where this research is happening
Storrs-Mansfield, United States
- University of Connecticut Storrs — Storrs-Mansfield, United States (Active)
Researchers
- Principal investigator: Hanlon, Stacey L — University of Connecticut Storrs
- Study coordinator: Hanlon, Stacey L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.