Understanding extra chromosomes and their effects on health
Investigating supernumerary chromosome biology using the B chromosome model system
This study is looking at extra chromosomes that can cause health problems like infertility and cancer, using fruit flies to learn more about how these extra chromosomes form and act, so we can better understand their impact on human health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Storrs NIH-funded |
| Lab location | 1 site (Storrs-Mansfield, United States) |
| Project ID | NIH-10940940 on NIH RePORTER |
What this research studies
This research investigates the biology of extra chromosomes, known as supernumerary chromosomes, which can negatively impact human health, including issues like infertility and cancer. By using a model system from fruit flies, researchers aim to explore how these extra chromosomes arise and behave. The study employs advanced DNA sequencing and bioinformatics to uncover the genetic factors involved. This work seeks to fill significant gaps in our understanding of how these chromosomes affect human development and health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing infertility or those with genetic conditions linked to chromosomal abnormalities.
Not a fit: Patients without any chromosomal abnormalities or related health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the causes of infertility and other health issues related to chromosome abnormalities.
How similar studies have performed: While research on aneuploidy is well-established, the specific focus on supernumerary chromosomes using this model system is relatively novel and has not been extensively tested.
Where this research is happening
Storrs-Mansfield, United States
- University of Connecticut Storrs — Storrs-Mansfield, United States (Active)
Researchers
- Principal investigator: Hanlon, Stacey L — University of Connecticut Storrs
- Study coordinator: Hanlon, Stacey L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.