Understanding Estrogen's Role in Muscle Strength as We Age
Interaction of estrogen, age, and activity on musculoskeletal strength in females
This project explores how estrogen, age, and physical activity influence muscle strength in both women and men.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11132947 on NIH RePORTER |
What this research studies
As we get older, many people experience a loss of muscle strength, which can affect their quality of life. This research focuses on how lower levels of estrogen, particularly in aging women, contribute to this decline in muscle function. We are also beginning to understand how estrogen impacts muscle in men. By studying the specific cellular and molecular processes involved, we aim to uncover the detailed ways estrogen affects muscle strength and how these changes occur with age.
Who could benefit from this research
Good fit: This research is relevant to adults experiencing age-related muscle weakness or those interested in the effects of estrogen on muscle strength.
Not a fit: Patients not experiencing age-related muscle weakness or estrogen deficiency may not directly benefit from this specific research.
Why it matters
Potential benefit: This work could lead to new strategies and treatments to prevent or reduce age-related muscle weakness and strength loss in both women and men.
How similar studies have performed: Previous research has shown that estrogen deficiency can cause strength loss, and this project builds on those findings to explore specific mechanisms.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Lowe, Dawn a — University of Minnesota
- Study coordinator: Lowe, Dawn a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.