Understanding epilepsy in baboons to improve treatments for humans
Preclinical Modeling of Neural Regulatory Networks in Baboon Epilepsy
This study is looking at genetic generalized epilepsies by using baboons to help us understand the condition better, so we can create more accurate models that reflect how epilepsy affects people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas San Antonio NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-11168260 on NIH RePORTER |
What this research studies
This research investigates genetic generalized epilepsies (GGE) using baboons as a model to better understand the condition that affects many adults. By studying the genetic and molecular characteristics of epilepsy in baboons, the researchers aim to develop a more accurate in vitro model that mimics human epilepsy. This approach is significant because traditional rodent models do not adequately represent the complexities of human epilepsy. The study will utilize advanced techniques, including induced pluripotent stem cells, to create cerebral organoids that reflect the molecular signatures of epilepsy seen in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic generalized epilepsy who have not responded well to existing treatments.
Not a fit: Patients with epilepsy that is not genetically generalized or those who have well-controlled seizures may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective anti-seizure medications for patients with epilepsy.
How similar studies have performed: While research using rodent models has been common, this approach using baboons is novel and aims to fill a critical gap in epilepsy research.
Where this research is happening
San Antonio, United States
- University of Texas San Antonio — San Antonio, United States (Active)
Researchers
- Principal investigator: Carless, Melanie — University of Texas San Antonio
- Study coordinator: Carless, Melanie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.