Understanding enzymes that play a key role in biological processes.
Official title: Radical SAM Enzymes: Radical Mechanisms Central to Biology
Funded at Montana State University - Bozeman · NIH-11057698 · Data updated 2026-11-12
This study is looking at special enzymes that help make antibiotics and fix DNA, with the hope that understanding how they work can lead to better treatments for conditions like Alzheimer's disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Montana State University - Bozeman NIH-funded |
| Lab location | 1 site (Bozeman, United States) |
| Project start | June 1, 2019 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $380,336 |
| NIH project number | 5R35GM131889-07 |
| Project ID | NIH-11057698 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals affected by Alzheimer's disease or related dementias.
✕Less likely to help
Patients with conditions unrelated to enzyme function or those not affected by Alzheimer's disease may not receive direct benefits from this research.
What this research studies
This research investigates radical SAM enzymes, which are crucial for various biological reactions, including the synthesis of antibiotics and the repair of DNA damage. By examining how these enzymes function, the research aims to uncover their mechanisms and properties, which could lead to advancements in medical treatments. The approach involves sophisticated techniques like freeze-quench trapping and spectroscopic analysis to study the enzymes in detail. Patients may benefit from insights gained about these enzymes, particularly in relation to conditions like Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating Alzheimer's disease and other conditions related to enzyme dysfunction.
How similar studies have gone: Other research has shown promising results in understanding enzyme mechanisms, suggesting potential for breakthroughs in related fields.
Where this research is happening
-
Montana State University - Bozeman
Bozeman, United States Active
Researchers
- Principal investigator: Broderick, Joan B — Montana State University - Bozeman
- Study coordinator: Broderick, Joan B
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.