Understanding Endometriosis Through Single-Cell Analysis
Leveraging Single-Cell Technologies to Elucidate Niche Environments and Immune Mechanisms Involved in Endometriosis Pathogenesis, Pathophysiology, and Disease Stratification
This work explores how immune cells and their surroundings contribute to endometriosis, a condition causing pain and infertility in many women.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11158749 on NIH RePORTER |
What this research studies
Endometriosis is a common condition where tissue similar to the uterine lining grows outside the uterus, leading to pain, infertility, and a reduced quality of life. We believe that the immune system plays a key role in how this disease develops and progresses. By looking at individual cells from these tissues, we aim to uncover the specific immune responses and cellular environments that drive endometriosis. This detailed understanding will help us create better ways to classify the disease and develop more effective treatments.
Who could benefit from this research
Good fit: This research focuses on understanding the disease mechanisms in women affected by endometriosis, particularly those experiencing pelvic pain and infertility.
Not a fit: Patients without endometriosis or those not experiencing symptoms related to the condition would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to improved ways to classify endometriosis and guide the development of new diagnostic tools and treatments for patients.
How similar studies have performed: While single-cell technologies are a cutting-edge approach, previous research has highlighted the significant role of the immune system in endometriosis, suggesting this approach builds on existing knowledge.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Giudice, Linda C — University of California, San Francisco
- Study coordinator: Giudice, Linda C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.