Understanding endometrial cancer outcomes in survivors
Official title: The Carolina Endometrial Cancer Study: A population-based survivor cohort
Funded at Univ of North Carolina Chapel Hill · NIH-11039968 · Data updated 2026-11-12
This study is looking into why Black women with endometrial cancer often have worse outcomes than others, and it aims to gather information from women in North Carolina about their experiences and treatments to help understand and improve these disparities.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $637,806 |
| NIH project number | 5U01CA281026-02 |
| Project ID | NIH-11039968 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women who have been newly diagnosed with endometrial cancer, particularly those from Black communities.
✕Less likely to help
Patients who do not have endometrial cancer or those who are not part of the targeted demographic may not benefit from this research.
What this research studies
This research investigates the factors contributing to racial disparities in endometrial cancer outcomes, particularly focusing on Black women who are disproportionately affected. It involves recruiting women diagnosed with endometrial cancer in North Carolina, with a specific emphasis on enrolling a significant number of Black women. The study will collect detailed medical histories, tumor samples, and conduct follow-up interviews to gather comprehensive data on treatment and survivorship experiences. By analyzing this data, the research aims to identify the underlying causes of disparities in cancer recurrence and survival rates.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies and survivorship care tailored to the needs of Black women with endometrial cancer.
How similar studies have gone: Previous research has shown success in addressing racial disparities in cancer outcomes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Nichols, Hazel B — Univ of North Carolina Chapel Hill
- Study coordinator: Nichols, Hazel B
Related research
Other NIH-funded projects on the same topics.
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Prognostic tools to guide adjuvant therapy for Black women after hysterectomy for endometrial cancer
A new project aims to create and validate easy-to-use tools that help doctors tailor post-surgery treatment for Black women with endometrial cancer.
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Understanding why guideline-concordant endometrial cancer treatment varies in high-risk groups
This project looks at why some patients with endometrial cancer don’t receive care that follows national guidelines, aiming to find ways to ensure more patients get the best-supported treatments.
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Targeting hormone resistance to prevent endometrial cancer
Aims to boost progesterone’s cancer-preventing effect in the lining of the uterus to stop cancer from developing in people at risk, especially those who are obese or young.
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Inhibiting AXL to Improve Treatment Response in Endometrial Cancer
A cancer treatment study is testing whether blocking AXL with batiraxcept together with standard chemotherapy can help people with certain aggressive uterine cancers respond better.
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Targeting HSPA Proteins to Help Women with Advanced or Recurrent Endometrial Cancer
Aims to test a drug called SHetA2 that may slow or stop growth of advanced endometrial cancer by targeting cancer-friendlier proteins, with a focus on reducing treatment toxicity.
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Endometrial Cancer SPORE: New strategies to prevent and treat endometrial cancer
A multi-institution program is testing new ways to prevent and treat endometrial cancer in people, with three linked projects and multiple cores to support translational research.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.