Understanding electrical signaling in brain cells involved in movement disorders
Official title: Electrical Signaling in Dendritic Branches
Funded at University of Connecticut Sch of Med/dnt · NIH-10950848 · Data updated 2026-11-12
This study is looking at how electrical signals in certain brain cells might affect movement problems in conditions like Parkinson's and Huntington's disease, and it will also test if some medications can help these cells work better.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Connecticut Sch of Med/dnt NIH-funded |
| Lab location | 1 site (Farmington, United States) |
| Project start | July 5, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $457,875 |
| NIH project number | 1R21NS138991-01 |
| Project ID | NIH-10950848 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with movement disorders such as Parkinson's disease or Huntington's disease.
✕Less likely to help
Patients with movement disorders not related to basal ganglia dysfunction may not benefit from this research.
What this research studies
This research investigates how electrical signals in specific brain cells, known as spiny projection neurons, contribute to movement disorders like Parkinson's disease and Huntington's disease. By examining the differences in electrical activity between two types of these neurons, the study aims to uncover the underlying mechanisms that lead to these disorders. The researchers will use advanced techniques to record electrical signals from the dendrites of these neurons, which are crucial for their function. Additionally, the study will explore how certain drugs may protect these neurons and improve their signaling.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better protect brain cells and improve movement control in patients with disorders like Parkinson's and Huntington's.
How similar studies have gone: Previous studies have shown promising results in understanding the role of electrical signaling in brain cells, suggesting that this approach may lead to significant advancements in treatment.
Where this research is happening
-
University of Connecticut Sch of Med/dnt
Farmington, United States Active
Researchers
- Principal investigator: Antic, Srdjan D — University of Connecticut Sch of Med/dnt
- Study coordinator: Antic, Srdjan D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.